In this episode, we take a closer look at seven (7) common gut-related roadblocks that can interfere with thyroid recovery. That includes foods like gluten, grains, and nightshades but also deeper layers like low stomach acid, gut infections, and hidden stress. You’ll also hear about environmental factors such as glyphosate and xenoestrogens that erode gut integrity over time.. If you would prefer to listen to the interview you can access it by Clicking Here.
Dr. Eric Osansky:
I am going to discuss seven gut healing roadblocks that can prevent you from restoring your thyroid health.
The first gut healing roadblock I’d like to discuss is eating gluten. Many people listening to this understand that they should be avoiding gluten while healing. One of the big reasons is because gluten is harsh on the gut. Research from I believe it’s 2015 shows that gluten can cause a leaky gut in everyone. That alone is reason to avoid gluten.
There is what’s called the triad of autoimmunity for those with Graves’ and Hashimoto’s as well as other autoimmune conditions. According to the triad, which I have discussed before, there is three components necessary for autoimmunity to develop.
There is a genetic predisposition, which we can’t do anything about. Then there is exposure to one or more environmental triggers, which we can find and remove. Then there is that increase in intestinal permeability, that leaky gut.
Eating gluten as well as other factors we will discuss here is one of the things that can cause a leaky gut and set the stage for an autoimmune thyroid condition. Even if you don’t have an autoimmune thyroid condition, it can still cause a leaky gut, which is not a good thing.
Gluten, at least while healing, should be avoided. There is an argument that we should all avoid it permanently. If someone is dealing with Celiac, then you definitely want to be strict about avoiding gluten, even avoiding cross-contamination. If someone has a non-Celiac gluten sensitivity, you also probably should be strict when avoiding it. Even if you don’t have Celiac or a non-Celiac gluten sensitivity, it’s still a good idea to avoid gluten, at the very least while healing.
When you have restored your health, you could decide whether or not you’re going to reintroduce gluten, even if it’s on an occasional basis. Some people definitely choose not to reintroduce gluten on an occasional basis. Let’s focus on healing first.
Sticking to the topic of gluten, some people wonder if the problem is really with glyphosate and not gluten. The reason they bring this up is because they might have traveled to Europe or have a family member or friend who traveled to Europe, and that person was able to eat wheat in Europe. Let’s say they went to Italy and had pizza and pasta that was not gluten-free, and they did fine.
I had Dr. Tom O’Bryan on the podcast, and I asked him this question. His response was that the reason why people do okay when they go to Europe is because in Europe, wheat is lower in FODMAPs. It’s a problem with FODMAPs. I discuss this in other episodes, for those who aren’t familiar.
He was saying that even when you go to Italy or other countries, gluten is gluten. It’s going to cause an immune response. It potentially can cause a leaky gut. Glyphosate is definitely an issue. I’ll mention glyphosate later during another gut healing roadblock. Regardless of where you are, whether you’re in the U.S. or in Europe or somewhere else, you really want to, especially while healing, definitely avoid gluten.
Let’s move on to gut healing roadblock #2: other foods that can be harsh on the gut. In addition to gluten, there are other foods that you want to at the very least take a break from while healing, or at least initially while healing. Some of the foods you are mentioning here, you might not need to completely avoid while healing.
This first one, I would say in most cases, is a good idea to completely take a break from until you have restored your health. That is grains, especially corn, but I would say other grains as well. I pick on corn a little bit because the research shows that corn can have a similar response to gluten.
There is a reason why grains are excluded not only from an AIP diet but also a regular paleo diet. They can be harsh on the gut.
I enjoy eating grains every now and then. Keep in mind I am in a state of wellness right now. I did avoid grains while I was healing when I dealt with Graves’ back in 2008-2009. Every now and then, I will have some gluten-free grains.
I understand that it is difficult to follow restrictive diets, even though there is a lot of variety with fruits and vegetables. Some people are used to eating rice or oatmeal on a regular basis. I would say to take a break from grains.
There is a really good book called No Grain, No Pain from Dr. Peter Osborne. If you want to learn more about the concerns with grains, you might want to check out that book.
Nightshades. This includes tomatoes, eggplant, peppers, white potatoes. Nightshades also have compounds including alkaloids and glycoalkaloids that could be harsh on the gut and cause inflammation.
The purpose of an elimination diet is to eliminate foods that could potentially be inflammatory that people commonly react to. We are not eliminating nightshades because of the sensitivities. I bring this up because I have had people do food sensitivity testing and show me the panel and say, “Hey, tomatoes are fine for me to eat,” etc. Again, we are not excluding nightshades while healing because of sensitivities. They could be harsher on the gut.
Similar with grains. If you do a food sensitivity test, and it shows that you’re not sensitive to certain grains, especially gluten-free grains, you might think, “Hey, why not have some of these grains?” Again, that’s not why we’re excluding some of these foods I am mentioning here.
That also includes nuts and seeds. Nuts and seeds are paleo-friendly, but they are not AIP-friendly. When I dealt with Graves’ back in 2008, there was no AIP diet back then. They weren’t gut-healing diets, but I followed a paleo diet initially. I hit a roadblock in my recovery, and I wasn’t a big egg eater at the time. I cut out nuts and seeds, and then I saw improvement in my progress. That seemed to be a roadblock in my case. I didn’t exclude them for too long; it was maybe about three months that I cut them out.
Just like nightshades, nuts and seeds have good health benefits. They are a good source of mono and saturated fats. They can be harsh on the gut though. Another reason to consider avoiding them.
There are some people I work with, even those with Graves’ or Hashimoto’s, who choose to continue eating nuts and seeds. They might follow a paleo diet rather than an AIP diet, and some of these people do okay. Some of these people don’t do okay. They might hit a roadblock. That’s why I encourage people to follow AIP initially. If someone is absolutely opposed to following AIP, but they are willing to follow paleo, then let’s see how you progress just doing paleo.
I do want to mention dairy. I haven’t come across research that shows that dairy specifically causes a leaky gut. Dairy can be inflammatory in some people. It’s a common allergen. If you are going to eat dairy, you definitely want to eat healthier forms of dairy, like drinking A2 milk or raw dairy, and not the pasteurized, homogenized dairy. Even while healing, it’s a good idea to take a break from dairy, mainly because it’s a common allergen, not because it will cause a leaky gut.
Like I said, the research is more clear with gluten as well as corn.
I also wanted to bring up legumes. Legumes, like grains, are excluded from both a paleo and AIP diets. Legumes do have some really good health benefits. If someone is a vegan, they might not be able to get protein from other sources.
In my book The Hyperthyroid Healing Diet, I talk about different types of diets. One is a level one diet, which is a modified Plant Paradox diet. A Plant Paradox diet is from Dr. Steven Gundry.
If someone is a vegan, because otherwise they won’t get enough protein, I think it’s okay for them to have some pressure-cooked legumes. Legumes, lentils do have some good health benefits. They could also be a little harsh on the gut. Again, pressure cooking them properly will minimize that.
This is one that is more debatable. I would say if you want to play it safe, avoid legumes while healing. If you absolutely want to have them, especially if you’re a vegan/vegetarian, then you might be okay eating legumes.
Let’s move onto gut healing roadblock #3: drinking alcohol. Alcohol should be completely avoided while healing. Even after healing, you want to minimize it. A lot of people think about the stress that alcohol puts on the liver, which is true; alcohol does put stress on the liver, but it also puts stress on the gut. It can increase permeability of the gut.
Are there exceptions? For example, red wine, white wine. They have some good benefits. There is a little bit of controversy in the research. Some studies show that red wine can cause a leaky gut. Some show that the polyphenols can benefit the gut microbiome. I think red wine, without question, as well as white wine do have some good health benefits. It’s not all bad. But still the alcohol can increase permeability. I would say try to take a break if you’re a wine drinker.
Same thing with other types of alcohol. Some people might like beer and ask if they can drink gluten-free beer. It’s not just the gluten we are talking about here; it’s the alcohol.
Another question I sometimes get asked is about alcohol from herbal extracts. With herbal extracts, these usually have such a small amount of alcohol. Even if it says 50% alcohol, if someone is taking a teaspoon, so they are getting 2.5ml of alcohol per serving, even if they are taking a few servings per day, it’s usually not going to be enough to cause a leaky gut. Everything comes down to risk versus benefits.
You might wonder about an alcohol-free extract. Something that uses glycerin instead of ethanol. It’s an option, but the reason why ethanol is used is because it’s really a good solvent. It’s a lot better than glycerin. It does a better job of extracting the phytonutrients from the herb. In other words, if you’re using alcohol-based tinctures or extracts, you will get greater benefit from the herb you’re taking.
If you’re sensitive to alcohol, then take something that has glycerin, like a non-alcoholic extract. I wouldn’t avoid an alcoholic extract because of the concern that it might affect the gut.
When I dealt with Graves’, I took bugleweed and motherwort, so I took two different liquid herbs that had alcohol. Everything turned out fine. Over the years, a lot of my patients have taken liquid bugleweed and motherwort or other herbs. Very small amount. It’s different than having a cup of red wine or other alcoholic beverages.
Let’s move on to gut healing roadblock #4, which is low stomach acid. Keep in mind that some of the other roadblocks that I’ll be discussing will cause low stomach acid, which I’ll also discuss here.
Low stomach acid is common. Stomach acid of course is important for digestion, helping break down nutrients, especially minerals. Also important for protein digestion. Also helps to keep harmful gut pathogens in check. You want to have healthy levels of stomach acid. There are other benefits as well. It helps activate digestive enzymes.
The problem is that the symptoms of low stomach acid and high stomach acid can be similar. Also, not everyone with low stomach acid will have symptoms. If someone has symptoms such as heartburn or reflux, most medical doctors will associate this with too much stomach acid. As a result, they will recommend an acid blocking medication, so a proton pump inhibitor. If someone takes that on a short-term basis, if you could avoid it, great. It’s more of a concern when someone is taking it long-term. A lot of people take these acid blocking medications for months, even years.
It’s a problem because I’m not saying there is not a time and place for taking it long-term, but some doctors will just give it to their patients long-term and never try to address the cause of the problem.
A lot of times, it could be a low stomach acid problem, not too much stomach acid. That being said, you do need to be careful. It could be too much stomach acid, too.
I like butane HCl; it’s in my digestive enzyme, Enzymes Plus. It has a smaller amount than what’s in a separate butane HCl supplement. Most people seem to tolerate it well. If someone has too much stomach acid, taking a separate butane HCl supplement might be too much and might cause heartburn or other symptoms.
There is something called the butane HCl challenge. That actually involves taking butane HCl to see how you respond. If you take butane HCl or a digestive enzyme that has butane HCl, even though it’s a smaller amount, and feel heartburn, for example, that might mean that you have enough stomach acid. In some cases, too much stomach acid, and then you should back off.
With the butane HCl challenge, if you take a separate capsule of butane HCl and do fine, and you always want to do this with meals high in protein, at least 10-15g of protein. Never do this on an empty stomach.
If you are fine taking a single capsule, according to the challenge, you’d want to take a second capsule. If you do fine with a second capsule, then add a third capsule. If you then get some heartburn, that’s telling you that’s too much, and you want to back down to the two capsules. Take two capsules of butane HCl per meal while trying to figure out what the cause of the low stomach acid problem is, so you don’t have to rely on butane HCl on a long-term basis.
There are other things you can do such as bitter herbs you can take. Ultimately, you want to try to address the cause of the low stomach acid. One potential cause is an underactive thyroid, so low thyroid could be a factor. This doesn’t mean if you have hyperthyroidism, you can’t have low stomach acid. Chronic stress could also cause low stomach acid, and a lot of people deal with chronic stress, including me when I dealt with Graves’.
H-pylori could cause low stomach acid. H-pylori is very common in those with autoimmune thyroid conditions such as Graves’ and Hashimoto’s.
Let’s discuss gut healing roadblock #5. Speaking of chronic stress, that’s what this roadblock is, as well as imbalances of the parasympathetic nervous system. These two are related.
Chronic stress decreases secretory IgA, which lines the mucosal surfaces of the body, including the gastrointestinal tract. It’s not a leaky gut marker, but if you have low secretory IgA, usually relates to a leaky gut.
I used to do a lot of leaky gut testing. I noticed that just about everybody who had a low secretory IgA also tested positive for a leaky gut. Secretory IgA serves as protection. You definitely want to have healthy secretory IgA levels. A lot of people deal with chronic stress. A lot of people do have lower or depressed secretory IgA.
Also, chronic stress causes imbalances in the parasympathetic nervous system, which is the rest and digest system. Having imbalances here can lead to digestive issues. It can also cause mood disorders, like anxiety.
What can you do? No matter how good you are at managing stress, it’s always going to be a factor. The problem is most people don’t do anything to manage stress. Even if you block out time to manage stress, it still might be a factor, but blocking out time for stress management still could be greatly beneficial.
I recommend blocking out five minutes per day to start. Even just doing some simple deep breathing. Walking, exercising. I know walking is relaxing. I’m not saying it’s not a form of stress management. You want things that really activate your parasympathetic nervous system. If you are doing cardiac exercise, like cardio exercise or resistance exercise, that is more of a sympathetic activity.
Doing some deep breathing five minutes per day can help. Of course, longer than this is better. The goal is to get into the routine of stress handling. If you’re in the routine of blocking out five minutes per day seven days a week, you could start increasing the duration.
Another thing you could do is incorporate Vagus nerve exercises. Mind/body medicine is stimulating the Vagus nerve. That’s a Vagus nerve exercise. Vigorous gargling is another Vagus nerve exercise. Singing out loud, either in the shower or in your car. It doesn’t matter where it is. That also stimulates the Vagus nerve.
Cold showers. Cold plunges, too. I can’t say I’m a big cold plunger. I’m not a big fan of cold plunges personally; it’s something I don’t do, but I do cold showers. Rotate hot and cold showers. If you are willing to do cold plunges, that could also activate the Vagus nerve. Vagus nerve exercises can make a big difference as well.
Gut healing roadblock #6: gut infections and overgrowths. I mentioned H-pylori. That’s something I commonly see. It definitely could affect the gut. I mentioned how it could be a factor with low stomach acid and could potentially increase permeability of the gut.
Parasites also could affect gut permeability. There are other infections. I won’t name all of them here. I will say Yersinia enterocolitica is another one. Giardia is a parasite. There are a lot of infections that could affect permeability of the gut. Not all of them will.
If you do a comprehensive stool panel, and you see some dysbiosis, which is imbalance of the gut flora, it doesn’t always mean that you’re going to have a leaky gut, for example. It really depends on which and how many microbes are out of balance.
Candida is not an infection, but you could have too much candida, so a candida overgrowth. That could affect permeability of the gut.
There is also SIBO, small intestinal bacterial overgrowth. This can also lead to an increase in intestinal permeability.
Gut infections and overgrowths are reasons why some people don’t heal. In most cases, testing is the best way. It’s not perfect. For parasites, you could do testing and have false negative results with all of these.
I do like testing though. I know there are practitioners out there, including some who have been on the podcast, who don’t like testing. They just treat everybody for parasites and other things without testing.
I realize it’s a catch-22. It’s not perfect, and the testing is not free. It can get expensive when you do functional medicine testing. If at all possible, I’d like to identify what is actually causing the leaky gut when it comes to gut infections and overgrowths.
If we’re suspecting a parasite, and we do testing that comes back negative, at that point, I’m okay with treating the parasite. I usually like to confirm it. Admittedly, it can be challenging. Obviously, different perspectives out there.
The seventh and final gut healing roadblock I’d like to discuss is environmental toxins and toxicants. Certain environmental toxins and toxicants can disrupt the gut and/or prevent it from healing.
I mentioned glyphosate earlier. It is the active ingredient in the herbicide Roundup. It can cause dysbiosis, which in turn could cause that increase in intestinal permeability.
Xenoestrogens, including microplastics, act as endocrine-disrupting chemicals. They could directly affect the thyroid. They also have been shown to affect permeability of the gut. I didn’t know this until recently. I have done a lot of research over the years with xenoestrogens, but I didn’t realize the impact they could have on the gut barrier. Another reason you want to minimize your exposure to plastics.
Mycotoxins from mold can potentially affect the intestinal barrier.
Certain heavy metals, including mercury, can also affect the intestinal barrier and the thyroid directly and the immune system in different ways.
Medications of course. Antibiotics, we all know that they can cause a leaky gut. I mentioned PPIs before. These also can cause a leaky gut. Plus they block the acid, which breaks down nutrients, so you don’t have that ability or an impaired ability.
I mentioned stomach acid is important for keeping bacteria and other pathogens in check. If you are taking acid blockers, it will make you more susceptible to gut infections and overgrowths, which is another roadblock.
For those with hyperthyroidism, antithyroid medication also can disrupt the gut. Risk versus benefits. This doesn’t mean that you should not take antithyroid medication and never take antibiotics. There is a time and place for these.
I have worked with a lot of people over the years who have taken antithyroid medication, such as methimazole or PTU, and were able to restore their health. It might take a little bit longer. Everybody is different. Depends on how high of a dose of medication you’re taking. Like I said, it’s all risk versus benefit. Without question, the research shows they can affect the gut.
These are the seven gut healing roadblocks that could prevent your thyroid from healing. As usual, I hope you found the information to be valuable. I look forward to catching you in the next episode.