This episode explores the real benefits and limitations of LDN for autoimmune conditions like Hashimoto’s and Graves’ disease. I share what the research actually says, why results are mixed, and why LDN should never replace the foundations of thyroid healing. If you would prefer to listen to the interview you can access it by Clicking Here.
Dr. Eric Osansky:
Have you ever come across low dose Naltrexone (LDN) as a way to lower thyroid antibodies? Maybe you have even wondered, is this the missing piece for me? LDN gets a lot of attention because it can modulate the immune system in certain cases.
Here’s the challenge. It doesn’t work for everyone. Some people see their thyroid antibodies drop. Others notice no change at all. A few even struggle with side effects. The real danger comes when LDN is assumed to be the answer. If it doesn’t deliver, you’re left feeling discouraged, questioning your next move. The lack of results might even be the last straw and cause you to choose radioactive iodine or thyroid surgery. Or if you are dealing with Hashimoto’s, the only solution is to stay on thyroid hormone replacement permanently. There is a time and place for this, but the point is, if you take LDN and it doesn’t work, there are other options.
In this episode, I do want to walk you through what LDN can and can’t do and how to think about it in the bigger picture of thyroid healing, especially if you’re trying to decide whether you’ve truly explored your options before committing to something permanent.
Let’s briefly talk about what LDN is. I have spoken about this in other episodes. I have had guests also talk about LDN. Naltrexone was originally used for opioid addiction. At lower doses, hence the name LDN, it can modulate immune activity as well as reduce inflammation. Typically, for years, doses like 1mg-4.5mg or 5mg were used. Still to this day, it’s used. I’ve had practitioners on the podcast who mentioned they are using a little bit higher doses, up to 10mg or 12.5mg, which apparently is still considered to be low dose.
As far as why LDN is considered in autoimmunity, the main reason is because it has the potential to calm the immune overreactivity in autoimmune conditions such as MS, Crohn’s, Hashimoto’s, and Graves’.
As far as the research goes, it is limited. There is not a lot of studies showing that LDN is successful in lowering thyroid antibodies, or auto antibodies. When it comes to thyroid antibodies, I am pretty sure there is no research I am aware of specifically showing that LDN can lower antibodies in those with Graves’ and Hashimoto’s.
That being said, over the years, even though most of my patients with Graves’ or Hashimoto’s don’t take LDN, I have had a good amount taking LDN from a different practitioner. Also, I’ve had practitioners on the podcast, like functional medicine practitioner who recommend LDN to pretty much all of their autoimmune patients. The reason they do that is because they see results, maybe not in everybody, and we’ll talk more about that. It’s an option to consider. If you are looking for research in the published journals, specific to Graves’ or Hashimoto’s, you probably won’t find anything.
Let’s talk about the upsides and downsides, starting with the upsides. Overall, LDN is safe. It is a medication, but when compared to, let’s say for those listening to this who have Graves’, and are familiar with antithyroid medication such as methimazole and PTU, those come with a lot of side effects. Some people tolerate them well, but they are known for their side effects.
For Hashimoto’s, taking thyroid hormone replacement, side effects are minimal.
With LDN, there are potential side effects such as sleep disturbances, which can be common. Most people do tolerate it. It’s also low cost and easy to get, especially in the United States. If you have a local practitioner who isn’t willing to prescribe LDN, you can visit a website. One of the ones I like is LDNDirect.com, where for about $100, you can speak with a practitioner remotely, and they almost always will prescribe LDN.
If you live overseas, there is LDNScience.org. You can use this in the United States, too. You can also go to your local pharmacy and ask them if they know anybody local who prescribes LDN.
There is the upside that it can potentially modulate the immune system. Also, side effects are minimal. Low cost. Not too challenging to get a prescription in most cases.
As far as the downsides and limitations, it does not address the root causes. LDN is not a substitute for eating a whole, healthy foods diet; managing your stress; getting sufficient sleep; incorporating regular movement; healing your gut; reducing your toxic burden. Assuming you want to address the cause of the problem, you still want to do that.
Another downside is some people don’t tolerate it. I mentioned sleep disturbances as common. Mood shifts, sometimes headaches. Not as common. Sleep issues are somewhat common. Some people take it at night, and they have issues sleeping. Their prescribing doctor recommends to take it earlier in the day.
Another downside is the risk of false hope, or should I say unrealistic expectations. Thinking that that will be it. I take LDN, and everything is great. To be fair, there are some people who take LDN, and that’s all they do. Just like some people take thyroid hormone replacement with Hashimoto’s, and that’s all they do.
The difference is that thyroid hormone replacement is hormone replacement; LDN is modulating the immune system. Either way, neither one are doing anything for the cause of the problem.
One can argue that LDN is better in a way because thyroid hormone replacement isn’t doing anything for the immune system component of Hashimoto’s. Someone might take thyroid hormone replacement, and the immune system is still damaging the thyroid gland. If LDN is working, it should prevent that from happening. Even if it does work, it doesn’t always work long-term.
That’s another downside. It is hit or miss. I think moreso with Graves’ than Hashimoto’s, for whatever reason, it’s more miss. It can work with Graves’, but that’s something to keep in mind. It doesn’t work in everyone. Even if it works, and you choose to take it long-term, it might stop working.
It is an option to consider, especially if your endocrinologist is pressuring you to get radioactive iodine or thyroid surgery with Graves’, and you are not doing well with antithyroid medication. Maybe you have even tried natural agents such as bugleweed or higher doses of L-carnitine, which also didn’t help, so you’re stuck. I really don’t want to get surgery or radioactive iodine. Maybe you are looking into something like LDN.
I mentioned how LDN is hit or miss. Over the years, I’ve had a decent number of people take LDN. I don’t have prescribing rights, so I am not prescribing it. They’re either working with another functional medicine practitioner while working with me who recommends LDN.
A lot of times, what happens is they took it in the past, or they are working with me now but in the past took LDN. I have had cases where someone took LDN, and it really didn’t work, or maybe had minor improvements. No major antibodies shifted. They came to see me, and we addressed the underlying cause of the problem.
Admittedly, this is challenging. I am not making out like it’s easy to do that. Again, I have seen cases where the LDN didn’t help, and they saw me and we addressed the cause of the problem, and it did help.
Another challenge is if you are taking LDN and simultaneously trying to address the cause of the problem. If you have antibodies lowering significantly, you don’t know if it’s related to the LDN or the natural approach. You would hope it’s related to the natural approach, but you’re also taking LDN for that purpose. You really wouldn’t know until you stopped taking the LDN under the guidance of the prescribing practitioner.
Everything comes down to risk versus benefits. If you feel like you’ve tried everything, if you have changed everything diet; blocked out time for stress management; are getting sufficient sleep; are doing things to reduce your toxic burden; maybe even did some functional medicine testing and found some triggers; no matter what you tried, nothing worked. Your antibodies still remain high.
Even though LDN is not addressing the cause of the problem, if you’ve tried everything, maybe that’s something to look into. I just wanted to remind you that it shouldn’t replace the foundations of healing. There is a time and place for functional medicine testing.
Sometimes, you may try something like LDN. You might expect clear progress. The thyroid antibodies gradually are improving over time. Remember that healing isn’t linear. It’s not just with LDN, as we are not really healing with LDN, but taking a natural treatment approach.
Everybody with a natural treatment approach will gradually see their antibodies decrease as they normalize, we hope, but sometimes it’s more of a rollercoaster ride. Sometimes, people hit roadblocks. Keep in mind, if one approach doesn’t deliver, it doesn’t erase the possibility of improving through other avenues. It’s easy to try many different things, whether it’s medications, supplements, protocols. What really makes a difference is clarity, knowing which tools are making an impact and which ones aren’t, and where your focus truly belongs.
Because this crossroads is so common, I did put together a recorded session that you can go through at your own pace. In it, I walk you through three areas that can make these decisions less overwhelming.
First, when permanent treatments like radioactive iodine or thyroid surgery are truly necessary, and when they are not the only option. Second, the overlooked triggers that keep thyroid antibodies high, even when things like LDN don’t make a dent. Third, a decision checklist you can use with your doctor, so you can feel more prepared and less pressured in your visit.
Too often, the conversation around medications like LDN becomes black and white. Either take it, or don’t. Most practitioners don’t recommend it at all. There are functional medicine practitioners who recommend it to all their autoimmune patients.
I want you to feel like you have more than two boxes to check. You can make a decision that reflects your unique situation. If you ever pin your hopes on something like LDN, and you have felt let down, this class can give you the perspective you have been missing. It’s available right now. You can go through it at your own pace. Or you can also visit SaveMyThyroid.com/Masterclass.
I’d like to thank you for taking the time to listen to this episode. Hope you found it to be valuable. Of course, I look forward to catching you in the next episode.

