Far too many people are living with misdiagnosed Graves’ or ignored hyperthyroidism and they don’t even know it yet. In this episode, I explain why these oversights happen, what red flags to watch for, and how to ask for the right labs. You’ll also hear how small clues like heart palpitations or low cholesterol can point to a bigger thyroid problem. My goal is to help you recognize the signs early and feel confident advocating for your health. If you would prefer to listen to the interview you can access it by Clicking Here.
Dr. Eric Osansky:
The other day, my wife got a call from a friend. I am friends with this friend’s husband. She said that her husband was diagnosed with elevated TPO antibodies. She wasn’t sure what TPO antibodies were and wanted to know if I could explain it to them. The doctor did some blood testing. All I really knew at that point in time was that the husband got TPO antibodies, and they were 135, something like that. I actually didn’t even look at the report. They didn’t send it to me. They just wanted to talk to me.
I ended up speaking with the husband. When I think about elevated TPO antibodies, a lot of people with hyperthyroidism do have elevated TPO antibodies. If that is the only thing they’re mentioning, I am thinking more hypo. My friend probably had elevated TSH, and they did TPO antibodies and found them to be elevated. He probably has Hashimoto’s.
I was speaking with him. One of the first things he mentioned was he was diagnosed with hyperthyroidism. At first, I wasn’t sure if he said “hyper.” If you say “hyper” and “hypo” fast, they sound similar. I repeated, “Did you say hyperthyroidism?” He said, “Yes, hyperthyroidism.” He was mentioning that he was fatigued. He knows from his research or what the doctor told him that fatigue is more common with hypothyroidism, but he has had a lot of fatigue. He isn’t losing weight. Essentially, he went to his primary care doctor, who ran some blood tests and told him he was hyper.
What I wanted to bring up is he also mentioned that he had blood tests about a year ago. Those blood tests apparently also showed that he was hyper, but they dismissed it. The medical doctor that he just saw mentioned that his last numbers were also hyper, but for whatever reason, they didn’t do anything.
I figured I’d have another episode focusing on hyperthyroidism just because with Hashimoto’s, it definitely does get misdiagnosed. Someone could have fatigue and weight gain, and maybe they do a TSH, and it’s within the lab range, but not optimal. It’s higher than it should be, higher than the optimal range. Without question, people with Hashimoto’s often get misdiagnosed or maybe not diagnosed at all.
Many times, doctors will just dismiss it and run the TSH. TSH might be 3.5, which is within the lab range. I can’t really say it’s misdiagnosed because that’s the range they use. It just gets ignored essentially for many years until the TSH gets to the point where it’s out of range, or the person goes to another practitioner, maybe even a functional medicine practitioner.
Anyway, my friend went to a primary care doctor. He didn’t get the Graves’ antibodies. He has another appointment in a couple of months, not until January 2026. I am recording this in mid-October 2025. Probably won’t be released for a little bit. He is waiting a couple of months to get the blood test, and then he has his follow-up appointment in January.
It sounds like he is on antithyroid medication. I asked him if it was methimazole or Tapazole. He wasn’t sure. He was out and about, but that is what I am thinking he is on. I told him he probably has Graves’ because if he had it last year, something like subacute thyroiditis will disappear. It could be Hashitoxicosis. That’s a possibility as well. He hasn’t had a thyroid ultrasound or seen an endocrinologist yet.
The point is that Graves’ can get misdiagnosed. Hyperthyroidism can get misdiagnosed. It can get overlooked or ignored. I wanted to bring up a few situations here.
There was a case report showing that a patient with a thyroid storm was actually misdiagnosed as having a panic attack because symptoms overlap heavily. That’s pretty scary. If someone goes to the ER, and they’re presenting with a thyroid storm, but they are told they have a panic attack. This is an extreme situation. I would imagine most of the time, a person who is experiencing a thyroid storm won’t just be told that they are having a panic attack.
The background is: “Graves’ is characterized by hyperthyroidism, and its symptoms often overlap with those with panic disorder, which may make it difficult to distinguish between the two conditions. In this report, we describe how proper diagnosis of thyroid disease in patients with mental illness can lead to appropriate treatment.”
They encountered a 34-year-old woman. Thyroid crisis from Graves’ was misdiagnosed as a panic attack. The patient was being managed as a case of panic disorder and bipolar disorder in a psychiatric outpatient setting.
About six months before the presentation, she had lost about 16kg in weight. A month before presentation, she developed several unpleasant symptoms as her condition worsened. Several weeks before, she had severe palpitations, tachycardia, discomfort in her throat. She visited the ER on a Sunday morning, presenting with nausea, severe tachycardia (elevated heart rate), fever, restlessness with anxiety, and we treated her as panic disorder with fever. Then noticed proptosis, bulging of the eyes. Considered the possibility of Graves’, and thyroid function tests were performed, even though data from her clinic was not available because it was a weekend.
In this situation, if it wasn’t for the woman’s eyes being suspicious, who knows? She might have been dismissed and labeled as having a panic disorder. Really scary.
I can’t say this happens a lot. I have had patients I have worked with with hyperthyroidism who have been to multiple practitioners. On average, hyperthyroidism does get diagnosed a lot quicker than hypothyroidism, but there are definitely exceptions. People get the runaround and have to go to multiple doctors.
I also wanted to bring up this other one from March 2025. Talking about how Graves’ therapies really haven’t advanced much. The abstract says up front, “Current therapies for Graves’ primarily aim to manage hyperthyroidism through synthetic antithyroid drugs, radioactive iodine, or surgery. However, these approaches are often limited by their incomplete efficacy, and the risk of inducing hypothyroidism.”
They talk about other potential treatments that are up and coming. At least they’re experimenting with them. They’re medications, not addressing the root causes. That’s another issue.
Same thing with Hashimoto’s. For many years, Hashimoto’s treatment was levothyroxine when you go to a medical doctor or endocrinologist. No different with hyperthyroidism. For many years, it’s been antithyroid medication, radioactive iodine, or thyroid surgery. If you bring up diet and lifestyle changes to most doctors, including endocrinologists, they will dismiss it as not being helpful. Very discouraging appointments.
A reminder that the goal of this podcast. There are a few goals. One is we are spotting misdiagnosis stories. Teaching listeners the red flags that can often get dismissed as anxiety, panic attacks, or other symptoms.
Another area which I need to focus more on is underdiscussed populations. I don’t talk a lot about children and teenagers because most of the people I work with are adults. I do see some children and teenagers as well. I have some episodes on that. I am not saying that should be the main focus, but probably something I do need to talk more about. There are other populations and things I should focus on more on this podcast.
Going over the science. Recently, I released an episode that spoke about L-carnitine and selenium in combination with methimazole. If you take those two with methimazole, you might need less methimazole, which is always a good thing. That was also a recent study. Always trying to keep up with the latest research in thyroid health and thyroid autoimmunity.
Now, what I’d like to do is talk about how to reduce the risk of misdiagnosis as a Graves’ patient. Hyperthyroidism without an autoimmune component, like toxic multinodular goiter. Of course, we need to know the symptoms that mimic other conditions. We just gave panic-like symptoms, anxiety. It’s sometimes difficult, and we will talk about other things you can do, like testing.
Anxiety, racing heart, tremors, sweating. That could be mistaken for panic attacks. Depression, fatigue, sleep issues, irritability, may be labeled as a mood disorder. Having weight loss and high appetite might be brushed off as having good metabolism or someone’s dieting.
When I dealt with Graves’, I lost a lot of weight and had a higher appetite. I was dieting, detoxifying, overtraining. Eventually, I saw a doctor because I developed a tachycardia. If I saw a doctor sooner, they might have said it was due to the dieting and exercising. That’s what I thought, too. I was intentionally trying to lose weight and figured because I was restricting calories—I wasn’t doing smart things back then—that’s why I had increased appetite.
Post-partum changes sometimes are written off as new mom stress or depression. It could be post-partum thyroiditis. We do need to pay closer attention to the person’s symptoms. The problem is with many medical doctors, they just don’t spend enough time with the patient. They of course have them fill out a comprehensive health history, or they should. Even then, they might probably just spend a minute or so skimming through that, going through that quickly.
Quite frankly, most medical doctors aren’t seeing a lot of people with hyperthyroidism walk into their office. When they have certain symptoms, that is probably not the first thing to come to mind.
You also need to do appropriate lab testing. TSH is usually what doctors start off with. I mentioned in the case of hypothyroidism, a lot of people are above the optimal range but within the lab range, so they are dismissed.
Hyperthyroidism is different. If someone has Graves’, TSH many times will be depressed. If the doctor or whomever orders the test and sees depressed TSH, if they haven’t ordered thyroid hormones, they should. Many times, they will just do a T4. Sometimes, TSH isn’t completely depressed. Sometimes, it takes time for that to happen. It could happen real quickly but not always.
You really want to do a full thyroid panel. At the very least, TSH and free T4. That is not a full thyroid panel. Not just TSH. You want to do TSH, free T4, free T3, antibodies. If you are suspecting Graves’, do TSI. I prefer TSI over TRAB. Still, that is better than not testing any antibodies.
In this case, even though my friend was hyper, he just had TPO antibodies tested. That is a drawback of seeing a conventional medical doctor. They are even less likely to see hyperthyroid patients. They just default to those TPO antibodies or sometimes TPO and TG antibodies in everyone, even if someone presents with hyperthyroidism.
Definitely want to do the right antibodies. If you want to do all three antibodies, nothing wrong with that, especially if someone is presenting with hyperthyroidism. Many misdiagnoses happen because only TSH is checked. TSH doesn’t tell the whole story.
Another thing is to be familiar with the red flag combinations. If you have rapid heartbeat and weight loss, I could understand where if you go to a primary care doctor, they might not catch on that it’s hyperthyroidism.
That’s also why you want to look at other aspects of one’s health history and do appropriate testing. If that same person has rapid heartbeat, weight loss, and some eye changes, especially bulging of the eyes, in that case, that was what made the people at the ER realize it wasn’t probably just a panic disorder but a good chance it was Graves’.
If someone is in post-partum, and they are having sudden mood swings and other symptoms, maybe the milk supply drops. If they are having tachycardia. Test the thyroid. Do some testing. Don’t assume it’s stress or mood related.
If someone does a lipid panel, and they see low cholesterol, which is very common with hyperthyroidism. I wouldn’t rely on the lipid panel because some people have elevated cholesterol with hyperthyroidism. Very common for people with hyperthyroidism to have low cholesterol, less than 150. LDL will also be lower. Most medical doctors don’t pay attention to low cholesterol, just high cholesterol.
If you go through a physical, and maybe they don’t do TSH at all, but you are experiencing symptoms. You have low cholesterol, and you’re probably going to have some other symptoms as well. Just low cholesterol would not justify doing a thyroid panel. There is a reason for low cholesterol. It could potentially be genetic, but it could be something else as well.
Advocate for imaging if needed. When I went to an endocrinologist back in 2008, I was already diagnosed with hyperthyroidism. I was referred to an endocrinologist, where I got the official Graves’ diagnosis. We could see I didn’t need an ultrasound. An ultrasound is not going to diagnose Graves’.
If you’re hyper and have positive TSI antibodies, that is pretty much diagnostic of Graves’. If you have hyperthyroidism and bulging eyes, you probably have Graves’. Some people do a radioactive iodine uptake test, which in many cases is unnecessary, especially if TSI is elevated in the presence of hyperthyroidism.
I asked for an ultrasound because I wanted to see if I had thyroid nodules. She palpated my thyroid and didn’t think I did. I still wanted that ultrasound. That’s why some will do the uptake test, if they want to see if the nodules are hot or cold. If they’re cold, there is a greater chance of them being malignant, but still only a 5% chance. It won’t confirm if someone has malignant nodules or not.
Also, don’t be afraid to seek a second opinion. Do so sooner than later. If you’re experiencing all these symptoms and they dismiss them as anxiety, panic attack, and if you don’t agree, or maybe you agree because they’re the expert, but they could be wrong. You might want to consider getting a second diagnosis.
Endocrinologists are not perfect, especially if you are looking for a natural approach. Usually, they do a good job of diagnosing. If you go to one GP, and they just say you have anxiety or panic attacks, you could go to another GP. Might want to see an endocrinologist.
I know it’s challenging because they might not even bring up thyroid. Why would you go to an endocrinologist if they are not thinking thyroid, and you aren’t thinking of thyroid? It could be challenging. If you have to go to another GP, then go to another GP. Hope that they do the appropriate testing.
Don’t be afraid to offer to pay for it. If they say your insurance might not pay for a thyroid panel, it comes down to diagnosis codes. If you have insurance, and they are putting in the right diagnosis codes, that they are suspecting it might be, that’s the thing about testing. You don’t know if it’s thyroid or not. That’s why you’re doing testing. If you knew, you wouldn’t have to do testing. Insurance isn’t going to deny the claim because the doctor ordered a thyroid panel, and it turned out to be normal. They did it to rule it out, to make sure.
I shouldn’t say that the insurance company won’t deny because they do crazy things. It comes down to proper diagnosis codes and all that good stuff.
Of course, look beyond thyroid labs. I mentioned some other symptoms are still important, even though you don’t want to rely on symptoms. If you get a bone density scan and have osteopenia or osteoporosis, there could be a lot of reasons for that. Could be hyperthyroidism. Maybe you had hyperthyroidism in the past. I would argue that most people who have low bone density don’t currently have hyperthyroidism.
The point is you need to keep an open mind. You need to really work with a practitioner who is not just going to rush you in and out. Trust your instincts as well.
If you are working with a natural healthcare practitioner, choose one who has experience with hyperthyroidism and Graves’. Doesn’t mean that has to be the main focus, like myself. It doesn’t have to be their #1 focus.
I would at least call the office or visit their website, and if they don’t have anything on their website about hyperthyroidism, that’s a big red flag. If none of the testimonials on their website talk about how they dealt with hyperthyroidism and restoring their health, that’s another red flag.
You could speak with an office worker and ask them some of the top conditions that the functional medicine practitioner works with. If they just say “thyroid,” I would dig deeper and ask about specific thyroid conditions. If they say “hyper” and “hypo,” then see what they have to say. If they just say, “hypothyroidism and Hashimoto’s,” another red flag.
The main purpose of this is to bring more awareness. That is the purpose of this whole podcast and other things I do. Hopefully, you found this to be valuable.
Also, I have been talking recently about my Healing Graves’ Naturally community. Living with Graves’ or other types of hyperthyroidism, you can feel incredibly lonely. You go online and search for answers, and most of what is online is about Hashimoto’s.
If you do see an endocrinologist, they will typically just tell you to take antithyroid medication or do radioactive iodine or surgery. Nobody explains why you have hyperthyroidism or Graves’. If you have Graves’, they don’t talk about what your antibodies mean. They might only test them a single time. It could be really confusing or overwhelming. At times, it makes you feel like you’re the only one going through this.
I do have a couple of Facebook groups. The problem with Facebook groups is they are so large. I don’t trust Facebook. They could shut down my groups at any time. They sometimes will randomly delete people’s comments. I still have my Facebook groups, but I also created a new community specifically for Graves’ and hyperthyroidism that is not on Facebook. It definitely is something I recommend checking out.
Inside this community, we focus on the answers you can’t find elsewhere. Right now, it’s smaller, and that’s the goal. The engagement is really great. Definitely would check it out. The name of the group is Healing Graves’ Naturally. A number of different benefits of being part of the community. Hope beyond the standard three options recommended by endocrinologists.
There is a time and place for antithyroid medication. A lot of people I work with are on methimazole, carbimazole, or PTU. Some like myself take natural agents like motherwort, bugleweed, or higher doses of L-carnitine. Obviously, the focus isn’t going to be on medication, radioactive iodine, or surgery. It will be on finding and removing triggers, healing the gut. You will obviously get guidance from someone who has been there in myself. It’s not exactly the same. You are not working with me one-on-one.
In the Facebook groups, I am just not present. Sometimes, I will do a random Q&A. I do some commenting, but I don’t spend a lot of time in there because in my hyperthyroidism Facebook group, as of recording this, there are almost 25,000 people. It’s just too big.
If I do post something, which I do regularly, they are very basic. Only a small amount of people see them because that’s Facebook’s algorithm. Anyway, you will get some support and guidance in the group. There is a lot of engagement from others in the group. Of course, evidence-based natural solutions as well.
Also, just to let you know, the group is free. I want to help as many people as I can. Eventually, my plan is probably going to become a paid group. I want to keep it small. The goal is not to keep it super small. I don’t want 10,000-20,000 people in the group. I think that’s too big. My perspective maybe will change. Today, you can join at no cost.
When you join, you also gain free access to my brand new Graves’ Survival Road Map Training. If you are interested, click in the show notes. Become part of the community that finally puts Graves’ and hyperthyroidism at the center of the conversation. I’m sure you’ll be happy that you did.
I am going to continue to spread the word. The interviews that I do will focus on both Graves’ and Hashimoto’s because most people I interview aren’t familiar with hyperthyroidism. You will see that not all but more of the solo episodes will focus on hyperthyroidism.
Hope you found this episode to be valuable. Look forward to catching you in the next one.

