A new study may have just changed how we think about two nutritional supplements that can benefit those with Graves’ disease. In this episode, let’s discuss how this combination may help lower thyroid antibodies, improve symptom control, and even reduce the total dosage of methimazole. If you would prefer to listen to the interview you can access it by Clicking Here.
Dr. Eric Osansky:
Hello, everyone. Welcome to another episode. In this episode, I am going to discuss a recent study on Graves’. This journal article came out in August 2025, a few months ago. It discussed how taking L-carnitine and selenium can be beneficial for Graves’ patients who are taking methimazole.
Even if you are not taking methimazole, I think this study is important, as it still demonstrates the benefits of combining selenium and L-carnitine. There have been separate studies showing the benefits of selenium and thyroid autoimmunity. There have also been a few studies showing that L-carnitine in larger doses—2,000-4,000mg—can block the entry of thyroid hormone into the cell. In some cases, it can be used as a substitute for antithyroid medication. I am not specifically telling you to use L-carnitine as a substitute.
This is the first study, I’m pretty sure, that looks at combining selenium and L-carnitine in Graves’ patients. This does involve patients taking methimazole, too, essentially increasing the effectiveness of methimazole. It still is worth exploring the possibility of taking selenium and L-carnitine by itself.
I’ll talk more about this because it’s not like I haven’t been recommending selenium to most of my Graves’ patients. L-carnitine, I can’t say I recommend it across the board. I definitely recommend selenium more frequently, but I have a number of patients who take L-carnitine, too.
Let’s talk more about the study. Again, I have the study in front of me, which I’ll make sure to include the link. I won’t read the study verbatim. Essentially, the trial asks: Can adding a combination of L-carnitine and selenium to standard methimazole therapy improve outcomes in new Graves’ patients?
It involved 60 patients with newly diagnosed overt Graves’. They were randomized into two groups, one with methimazole alone and another group with methimazole and a supplement containing L-carnitine and selenium.
The research is measuring thyroid hormones: free T3, free T4, TSH. It also looked at TRABs. I don’t think specifically the TSIs. You could test the TSIs in a blood test, but you could also test the TRABs. They looked at the TRABs. If you’re not familiar, TSI is thyroid stimulating immunoglobins, which is a type of TSH receptor antibody.
It also looked at symptom scores for every two months for up to 24 months. Patients also filled out the questionnaires about classic hyperthyroid symptoms, such as increased resting heart rate, tremors, heat intolerance, and irritability.
Let’s discuss some of the major findings. As far as what did not change significantly, the time for TSH, free T3, and free T4 to normalize was not significantly different between the two groups. In other words, by adding L-carnitine and selenium, it didn’t seem to speed up the normalization of thyroid hormone levels compared just to taking methimazole alone.
What did improve in those that took L-carnitine and selenium along with methimazole? First, the antibodies turned negative sooner, which is great. I mentioned before that there are a lot of people who take just methimazole. Most people are just taking methimazole. Some are taking selenium on their own. It’s not like people have to go full-out taking a natural approach.
The point is, methimazole is focusing more on the thyroid than the immune system, but there have been a good number of studies showing that selenium can influence the antibodies, which makes sense. It helps to reduce oxidative stress.
It’s not addressing the triggers. If you have other triggers, I could talk more about this. I don’t know of any studies showing that L-carnitine normalizes antibodies. In those taking L-carnitine, selenium, and methimazole, the TRABs turned negative sooner. That suggests the supplement they took may help with the autoimmune component of Graves’. That’s a big finding.
Also, another positive finding is those taking the supplements had a lower methimazole dosage, so they required less methimazole on average. Their total lifetime exposure to methimazole was significantly lower. That is another benefit.
If someone is on higher amounts of methimazole, let’s say 20mg, which is like a medium dose. 40mg is a higher dose. Perhaps a combination of that methimazole along with L-carnitine and selenium might allow the person to take a lower dose of methimazole.
Again, it’s not a surprise because L-carnitine has some antithyroid effects by blocking the entry of thyroid hormone into the cell. Selenium can affect positively that autoimmune response. It’s not addressing removing triggers or healing the gut, but it helps to reduce oxidative stress.
It makes sense that the combination of selenium and L-carnitine along with methimazole could result in less methimazole needed. I wish there was a study of bugleweed with selenium or bugleweed with L-carnitine or maybe all three. That study is not out yet.
A higher rate of remission is also another benefit. The supplement group had substantially higher frequency of going into remission without needing surgery or radioactive iodine.
We don’t know the relapse rate. We see that all the time with people who are just on methimazole. Months go by, and then the doctor mentions that the person is in remission. Then they are taken off the methimazole, and then perhaps a few months later, sometimes, longer than a few months, many times, if not most of the time, they will relapse.
The person could take lower amounts of methimazole, which is always a benefit. Methimazole commonly causes side effects. It also does affect the gut in a negative way. The less methimazole you can take, the better. Better symptom management as well.
There were some limitations of the study. It was not a blinded study. There was no placebo control. Patients and doctors may have known who was getting the supplements. This can influence symptom reporting or expectations. The symptom questionnaire that was used was not fully validated. The supplement dose and form matters.
It’s also worth mentioning that only 83mcg of selenium was taken, and only 500mg of L-carnitine was taken. I say “only” because I commonly recommend 200mcg of selenium, as do a lot of other practitioners. When it comes to L-carnitine, the other studies show that between 2,000-4,000mg of L-carnitine is what’s needed to block the entry of thyroid hormone into the cell. This study only used 500mg of L-carnitine. It would be interesting if different doses were used, too. 200mcg of selenium along with higher amounts of L-carnitine.
I also should mention that over the years, I’ve had a lot of people take selenium. The majority of people eventually take selenium. If you just started working with me, I don’t always give it after the first consultation. If I didn’t recommend it right off the bat, usually, I am recommending it by the second consultation.
L-carnitine, I don’t always recommend. From a symptom management standpoint, I’ve had a lot of success with bugleweed over the years. I typically recommend bugleweed initially. It depends. Some people do take bugleweed along with L-carnitine. Some people switch to L-carnitine after bugleweed doesn’t seem effective.
Even though not everybody takes selenium and L-carnitine in my practice, I have had a lot of people over the years take both. In higher doses, too, than what was used in the study. Again, it doesn’t always result in normalization of the antibodies. It’s something that people can definitely try. Keep your expectations in check.
Taking selenium and L-carnitine alone, they’re not addressing the underlying cause of the problem. You still want to do everything I talk about on this podcast. Many episodes talk about diet and lifestyle. Looking at other triggers, like infections, environmental toxins/toxicants, mold, heavy metals, microplastics.
This was encouraging. Don’t get me wrong. I’m glad they have this study. Like I said, it would be amazing if they released a similar study with bugleweed instead of or in combination with L-carnitine. I don’t know if that will get done unless I put it together, which I have never done. I would need some assistance doing that. It would be very interesting to see that combination.
Just wanted to share this new research study. It is specific to Graves’ patients. If you have another hyperthyroid condition, like toxic multinodular goiter, again, it’s not autoimmune toxic multinodular goiter. Some people with that condition can have an autoimmune component, but typically, they don’t. The L-carnitine might help with thyroid hormone. Of course, a lot of people with toxic multinodular goiter are also told to take methimazole. We wouldn’t be modulating the immune system like this study succeeded in doing.
I wanted to share this study. I found it interesting. Hope you found it interesting as well.
Also, I wanted to mention that if you’re dealing with Graves’ or a different hyperthyroid condition, it can feel incredibly lonely. You go online searching for answers. Most of what you find online is about Hashimoto’s. Most of the information is hypothyroidism. Most podcasts, too. This is the only one that has an emphasis on hyperthyroidism and Graves’.
When you go to your doctor, of course, they’re saying three things: take antithyroid medication, do radioactive iodine, or have surgery. No one explains why you have hyperthyroidism. For those with Graves’, they don’t explain what your antibodies mean. They might test you one time, and it might be a struggle to retest. Could be confusing, overwhelming. At times, it makes you feel like the only one going through this.
That’s one of the main reasons why I created a new community specifically for Graves’ and those with other types of hyperthyroid conditions that is not on Facebook. No one should have to walk through this alone, confused, unsupported. Inside this group, we focus on answers you can’t find elsewhere as well as give support that can make a big difference.
The name of the group is Healing Graves’ Naturally. Even if you have a different type of hyperthyroid condition, I think you can still benefit from joining.
I do have a hyperthyroid-related group on Facebook. But it is really large, which might sound appealing. It has close to 25,000 members as of recording this. To me, it is overwhelmingly large. I wanted something smaller. I wanted something off of Facebook because Facebook could close my group at any time.
As far as some of the benefits of this group, which is on a platform called School, it gives hope beyond the standard three options. You’re not going to hear about antithyroid medication, radioactive iodine, or surgery. Not to say others might not bring them up in the group, but the goal is to go beyond those three treatment options with natural root cause approaches.
Of course, you will get some guidance from someone who’s been there. I have been in your shoes. As you may know, I personally overcame Graves’. I know the fear of the rollercoaster of symptoms. I know what works and what doesn’t work.
I also talk about my process of the Save My Thyroid method I have been using to help people all over the world. For many years, I have been in remission since 2009. I have been working with other people ever since then.
Evidence-based natural solutions. That is what this episode was about: giving some updated research, practical science-backed strategies, nutrition, lifestyle, functional medicine insights.
Right now, the group is free. My goal is to help as many people as I can. At the same time, I don’t want it to get as big as Facebook. My plan is it will become a paid group eventually. It won’t be within the next few weeks or months, but it will most likely make the transition to a paid group.
Those who join for free will not have to pay anything. Once you’re in the group, you’re in. It won’t be a massive charge, but you might as well join for free while you can.
Also, as an incentive to join, you will also get free access to my brand-new Graves’ survival road map training. It’s not just a single video. This is almost like a course. I should call it one. It has eight modules. All you have to do is click a link in the show notes to join the community. You’ll be happy that you did.
Thank you so much for tuning into this episode. As usual, I hope you found this information to be valuable. Look forward to catching you in the next episode.

